New variant Creutzfeldt-Jakob disease.

First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features.

OBJECTIVE To describe the early psychiatric and neurological features of variant Creutzfeldt-Jakob disease. DESIGN Cohort study. SETTING National surveillance system for Creutzfeldt-Jakob disease in the United Kingdom. PARTICIPANTS The first 100 cases of variant Creutzfeldt-Jakob disease identified in the United Kingdom. MAIN OUTCOME MEASURES The timing and nature of early psychiatric a...

Diagnosis and Management of Creutzfeldt-Jakob Disease

Introduction Although Creutzfeldt-Jakob disease (CJD) is rare, its rapid course, its infection control implications and the link between bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease (vCJD) make this disease relevant to all clinicians. The emergence of vCJD has prompted an explosion in the amount of research into the disorder, leading to new developments in both diagnos...

Single photon emission computed tomography in the identification of new variant Creutzfeldt-Jakob disease: case reports.

New variant Creutzfeldt-Jakob disease may be associated with exposure to the causative agent of bovine spongiform encephalopathy. Currently, a reliable diagnosis is possible only after neuropathological examination of the brain, which is risky for patients and diagnosticians. The sensitivity and specificity of recently developed techniques are not known for new variant Creutzfeldt-Jakob disease...

Variant Creutzfeldt-Jakob disease.

Current evidence indicates that variant Creutzfeldt-Jakob disease is caused by the transmission of bovine spongiform encephalopathy to humans. The clinical and investigative features of variant CJD are relatively distinct from sporadic CJD and the neuropathological appearances are novel. The number of cases of vCJD in the UK may have peaked, but the total future number of cases of vCJD is uncer...

MRI detection of prion protein plaques in variant Creutzfeldt-Jakob disease.